Create a personalised ads profile. Select personalised ads. Apply market research to generate audience insights. Measure content performance. Develop and improve products. List of Partners vendors. A niacin flush is a side effect of taking large doses of niacin vitamin B3 supplements. The flush happens when the niacin causes the small blood vessels in your skin to dilate so more blood can rush through.
Almost everyone who takes large doses of niacin experiences this flush. It isn't harmful, but it can scare you if you don't know it's coming.
While no one needs large doses of niacin, some people take it as a supplement to reduce the risk of heart disease and atherosclerosis. Large daily doses of niacin may help to lower LDL cholesterol the bad cholesterol and increase HDL cholesterol the good form of cholesterol.
A niacin flush starts about 30 minutes after you take a large dose 30 to 50 milligrams or more. The flush includes reddening of the skin accompanied by a burning or itching sensation. The flush gets better over time and is usually gone within an hour or two.
The niacin flush is generally harmless, but may occasionally be accompanied by a headache, dizziness, or drop in blood pressure. If you experience these symptoms with a niacin flush, you should call your doctor for advice.
You won't get the niacin flush reaction after taking multiple vitamins that contain smaller amounts of niacin. If you think you might have overdosed on niacin, seek medical attention immediately. If you have liver disease, peptic ulcer disease or severe low blood pressure hypotension , don't take large amounts of niacin.
The supplement has been linked with liver damage, can cause hypotension and might activate a peptic ulcer. Taking niacin also might worsen allergies, gallbladder disease and symptoms of certain thyroid disorders. If you have diabetes, niacin can interfere with blood glucose control. Use niacin with caution if you have the complex form of arthritis gout. Niacin can cause an excess of uric acid in the blood hyperuricemia , putting you at risk of gout.
If you're pregnant, don't take prescription niacin for high cholesterol. However, if needed to prevent or treat niacin deficiency, niacin is likely safe to take during pregnancy and in breast-feeding women when used in recommended amounts. There is a problem with information submitted for this request. Sign up for free, and stay up-to-date on research advancements, health tips and current health topics, like COVID, plus expert advice on managing your health.
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By some reports, virtually every person who takes high doses of nicotinic acid experiences flush 6. Other medications, including some antidepressants and hormone replacement therapies HRTs , can also trigger flush 1. Niacin flush is a common reaction to high doses of niacin.
When niacin flush occurs, symptoms typically set in about 15—30 minutes after taking the supplement and taper off after about an hour. The symptoms mainly affect the face and upper body, and include 9 , 10 :. People generally develop a tolerance to high-dose niacin. So even if you experience niacin flush when you first start taking it, that will probably stop in time 1 , 8. Niacin flush can appear and feel much like a sunburn.
However, symptoms typically go away after an hour. People usually develop a tolerance to the supplements over time.
Doctors have long prescribed high doses of niacin to help people improve their cholesterol levels and prevent heart disease 5. Taking high doses of niacin has been shown to produce the following improvements in blood cholesterol and lipids:. People only experience these positive effects on blood fats when they take therapeutic doses of niacin in the range of 1,—2, mg per day 5. To put that in perspective, the recommended daily intake for most men and women is 14—16 mg per day 9 , Niacin supplements should be treated like a drug and only taken under medical supervision, since they can have side effects.
High doses of niacin are typically used to improve cholesterol and triglyceride counts. They should only be taken under medical supervision, since they carry a risk of side effects.
However, high doses of niacin can cause other, more dangerous side effects, although these are rare The most harmful of these is liver damage. One role of niacin is to release prostaglandins, or chemicals that help your blood vessels widen — improving blood flow and reducing blood pressure. For this reason, niacin may play a role in the prevention or treatment of high blood pressure 8. A high quality study also noted that single doses of mg and mg of niacin slightly reduced right ventricular systolic pressure 9.
Type 1 diabetes is an autoimmune disease in which your body attacks and destroys insulin-creating cells in your pancreas. On one hand, it can help lower the high cholesterol levels that are often seen in people with type 2 diabetes. On the other, it has the potential to increase blood sugar levels. As a result, people with diabetes who take niacin to treat high cholesterol also need to monitor their blood sugar carefully Fortunately, a more recent review of studies found that niacin did not have significant negative effects on blood sugar management in people with type 2 diabetes In fact, brain fog and even psychiatric symptoms are associated with niacin deficiency 1 , However, results are mixed 15 , It may help prevent certain types of skin cancer as well.
One high quality study in over people at high risk of skin cancer found that taking mg of nicotinamide twice daily reduced rates of nonmelanoma skin cancer compared to a control Niacin can help treat many conditions.
It appears to exert positive effects on blood fat and blood pressure levels, and may play a role in type 1 diabetes, brain health, and skin cancer prevention. However, more research is needed.
Niacin is found in a variety of foods, especially meat, poultry, fish , nuts, and legumes. Some foods may also be fortified with niacin and other vitamins, like breakfast cereals 1. Some energy drinks also list doses — sometimes high — of B vitamins Here are some common food sources of niacin, along with how much of the Daily Value DV they provide 1 :. Many foods contain niacin, especially meat, nuts, and legumes. Some foods are also fortified with extra B vitamins. However, supplemental doses can have various side effects, including nausea, vomiting, and liver toxicity 1.
Of particular note is one side effect known as niacin flush. This can occur when taking 30—50 mg or more of supplemental niacin in a single dose.
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